GOG 0218 PDF

GOG randomized, double-blind, placebo-controlled phase III trial: (A) study design; (B) progression-free survival analysis (reproduced with permission) Download scientific diagram | Design of Study GOG from publication: Time for a Level Playing Field: Inequalities in Regulatory/Approval Processes–The. ASCO Annual Meeting CHICAGO — The addition of bevacizumab as maintenance therapy to first-line treatment with standard.

Author: Zulkisida Kagam
Country: Vietnam
Language: English (Spanish)
Genre: Life
Published (Last): 11 July 2015
Pages: 73
PDF File Size: 6.55 Mb
ePub File Size: 9.97 Mb
ISBN: 645-2-35669-686-9
Downloads: 77727
Price: Free* [*Free Regsitration Required]
Uploader: Zulkicage

You may also go side effects to Genentech at Objective response rate ORR: Recommended dosing for approved cancer types. Your email has been sent!

Pregnancy warning Based on the mechanism of action and animal studies, Avastin may cause fetal harm Gig female patients that Avastin may cause fetal harm, and to inform their healthcare provider of a known or suspected pregnancy Advise females of reproductive potential to use effective contraception during treatment with Avastin and for 6 months after the last dose of Avastin Advise nursing women that breastfeeding is not recommended during treatment with Avastin and for 6 months following their last dose of treatment Avastin may impair fertility.

Bevacizumab Approved by FDA to Treat Ovarian Cancer Following Surgery

Dosing and Usage Doses and Duration. These data are likely to underestimate the true adverse event rates due to the reporting mechanisms used in this study.

Analysis not designed to evaluate statistical significance between treatment arms or compare among the 3 chemotherapy cohorts. Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites. Recurrent Glioblastoma GBM Avastin is indicated for the treatment of recurrent glioblastoma in adults. Do not administer Avastin for at least 28 days after surgery and got the wound is fully healed Discontinue in patients with wound healing complications requiring medical intervention Hemorrhage Severe or fatal hemorrhage have occurred Do not administer Avastin to patients with serious hemorrhage or recent history of hemoptysis Discontinue for Grade hemorrhage.


Efficacy data overview in ITT 018 [ 1 ]. Additional serious adverse events Additional serious and sometimes fatal adverse events with increased incidence in the Avastin-treated gig vs chemotherapy arm included: Overview of proposed MOA of Avastin.

The safety data was consistent with the goh safety profile established in first- and second-line MCRC 5. Avastin, in combination with fluoropyrimidine-irinotecan- or fluoropyrimidine-oxaliplatin-based chemotherapy, is indicated for the second-line treatment of patients with metastatic colorectal cancer who have progressed on a first-line Avastin-containing regimen.

Cohort analysis was exploratory. Median OS by chemotherapy cohort. OS results in patients with psOC who have not received more than 1 prior chemotherapy regimen [ 1 ] Median overall survival OS: The number of patients with measurable disease at baseline was in the Avastin plus chemotherapy arm and tog the chemotherapy alone arm Median OS: Efficacy Data Recurrent Glioblastoma Studies.

Avastin® (bevacizumab) Efficacy | Stage III or IV Ovarian Cancer & psOC, prOC

Metastatic renal cell carcinoma 028 Avastin, in combination with interferon alfa, is indicated for the treatment of metastatic renal cell carcinoma. The information contained in this section of the site is intended for U.

Efficacy data overview [ 1 ]. The link you have selected will take you away from this site to one that is not owned or controlled by Genentech, Inc. Avastin, in combination with carboplatin and paclitaxel, or with carboplatin and gemcitabine, followed by Avastin as a single agent, is indicated for the treatment ggog patients with platinum-sensitive recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer.


Click “OK” if you are a healthcare professional.

Persistent, recurrent, or metastatic cervical cancer CC Avastin, in combination with paclitaxel and cisplatin or paclitaxel and topotecan, is indicated for the treatment of patients with persistent, recurrent, or metastatic cervical cancer.

Summary of efficacy data from Avastin pivotal trials.

Bevacizumab Approved by FDA to Treat Ovarian Cancer Following Surgery

PFS data are based on investigator assessment. Study design and patient population [ 1,54 ]. The GOG study evaluated Avastin plus chemotherapy vs chemotherapy alone in platinum-sensitive ovarian cancer [ 1,3 ]. Recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer rOC Avastin, in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan, is indicated for the treatment of patients with platinum-resistant recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer who received no more than 2 prior chemotherapy regimens.

ORR by chemotherapy cohort. Genentech does not recommend and does not endorse the content on any third-party websites. Prescribing Information Register for Updates References. Avastin plus chemotherapy carboplatin and paclitaxel demonstrated a 5.