PRODUCT MONOGRAPH. PR. Cathflo. ® alteplase, recombinant . cell line into which the cDNA for alteplase has been genetically inserted. Read all of this leaflet carefully before you What Actilyse Cathflo is and what it is used for. 2. Contents of the pack and other information. 1. Drug monographs for CATHFLO ACTIVASE provide an overview of the drug Keeping the vial of Sterile Water for Injection upright, insert the piercing pin of the .

Author: Kazrak Mozragore
Country: Honduras
Language: English (Spanish)
Genre: Literature
Published (Last): 27 July 2014
Pages: 147
PDF File Size: 10.78 Mb
ePub File Size: 15.96 Mb
ISBN: 275-7-89161-485-1
Downloads: 93086
Price: Free* [*Free Regsitration Required]
Uploader: Arashigul

This age group was excluded from acute ischemic stroke clinical trials evaluating the expanded alteplase use window. If Garlic supplements are taken, monitor appropriate parameters to attain proper clinical endpoints. Certain causes of catheter dysfunction should be considered before treatment with Cathflo Activase e. Contraindications Cathflo Activase should not be administered to patients with known hypersensitivity to alteplase or any component of the formulation.

Adverse Reactions In clinical trials, the most serious adverse events reported after treatment were sepsis, gastrointestinal bleeding, and venous thrombosis. Severe Aprotinin interferes with fibrinolysis ccathflo inhibiting the actions of kallikrein and plasmin, and it could inhibit fibrinolysis by thrombolytic agents. Major Patients receiving thrombolytic agents are at increased risk of bleeding during drotrecogin alfa therapy. Preparation of bolus dose: There was no statistically significant difference in INRs between the placebo cathfllo treatment period within each group.

We have a few patients who are fibrin producers, so form the sheath.

Cathflo Activase (alteplase) dose, indications, adverse effects, interactions from

However, based on the drug’s large molecular weight and short half-life, experts state that clinically significant amounts of drug are not expected to be found in breast milk. We do not treat before we are assured that the line is patent and in the right place.

The link you have selected will take you away from this site to one that is not owned or controlled by Genentech, Inc. If wait time is an iss Limited studies in patients with myocardial infarction and patients with thromboembolic disease indicate that the terminal half-life of alteplase is approximately 45 and 30 minutes, respectively.


PDR Search

Moderate Green tea has demonstrated antiplatelet and fibrinolytic actions in animals. Sodium Hyaluronate, Hyaluronic Acid: The link you have selected will take you away from this site to one that is not owned or controlled by Genentech, Inc. Caution should be exercised with patients who have any condition for which bleeding constitutes a significant hazard. You may also report side packagr to Genentech at It is unknown whether alteplase crosses the placenta or is excreted into breast milk.

Moderate Due to the thrombocytopenic effects of folate analogs, when used as antineoplastic agents, an additive risk of bleeding may be seen in patients receiving concomitant thrombolytics. Infants, Children, and Adolescents. The information contained packaage this section of the site is intended for U.

There is no efficacy or safety information on dosing in excess of 2 mg per dose for this indication. Using Cathflo Activase in patients with infected catheters may release a localized infection into the systemic circulation.

All ONS Member Community – Oncology Nursing Society

If you have ctahflo, don’t bother checking after the first 30 minuets. Long-term studies in animals have not been performed to evaluate the carcinogenic potential or the effect on fertility.

Prothrombin times stabilized during administration of both agents will change slightly when heparin is discontinued.

Delays in treatment are always a concern when you have a clotted catheter. However, the use of 0. Gently irrigate the catheter with 0.

All ONS Member Community

Hypersensitivity Hypersensitivity, including urticaria, angioedema and anaphylaxis, has been reported in association with use of Cathflo Activase. The bolus dose may be prepared in one of three ways: Heparin therapy either during or immediately following thrombolytic therapy has been recommended; the loading dose may packaye omitted. Withdraw 2 mL 2 mg of solution from the reconstituted vial. Cathflo Activase should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Moderate An additive risk of bleeding may be seen in patients receiving dalteparin in combination with other agents known to increase the risk of bleeding such thrombolytic agents.

If wait ctahflo is an issue we get an order for a chest xray to confirm proper portacath placement. Cathflo Activase should be used with caution in the presence of known or suspected infection in the catheter.


As with all catheterization procedures, care should be used to maintain cathfo technique. Thank you to all who responded to my post and for the helpful information about how other practices manage Cathflo Activase for their cathrlo lines.

These types of conditions should be considered before treatment with Cathflo Activase. The most frequent adverse reaction associated with all thrombolytics in all approved indications is bleeding.

Pregnancy There are no adequate and well-controlled studies in pregnant women. We follow the manufacturer’s instructions of allowing a dwell time up to minutes checking periodically after 30 minutes for blood return. Promptly evaluate any signs or symptoms of blood ibsert in patients on concomitant therapy. For multiple lumens, treat one lumen at a time. Patients receiving warfarin that initiate concomitant icosapent ethyl therapy should have their INR monitored more closely and the dose of warfarin adjusted accordingly.

Infections Packae Activase should be used with caution in the presence of known or suspected infection in the catheter. Your use of third-party websites is at your own risk and subject to the terms and conditions of use for such sites.

We often check for a blood return after 60 minutes if there is no blood return at 30 minutesbut if there is still no blood return, we typically report this and request an order to treat the patient in the absence of a blood return of course, we would have assessed how the port flushes, for any other signs of problems, and would not administer a vesicant agent in the absence of a blood return.

The reconstituted product contains no antibacterial preservatives and should be reconstituted immediately before use. Administration time varied but typically continued until complete lysis was achieved or for up to 12 hours.